CST Announces Availability of GMP-Grade CAR Linker Antibodies for CAR-T Cell Enrichment and Detection in Clinical Manufacturing and QC
Incorporate robust, flexible CAR-T Cell Enrichment and Detection into Your Manufacturing and QC Workflows.
CST transformed preclinical CAR cell characterization with universal recombinant monoclonal antibodies specific to the ubiquitous Whitlow/218 and G4S linker sequences of scFv-based CARs. This innovation enabled scientists to use a single reagent for a variety of assays without the time or cost of developing anti-idiotype antibodies for every CAR construct.
These trusted antibody conjugates, now manufactured to be GMP-grade, are intended to simplify enrichment of G4S linker CAR+ cells and increase productivity for in-process QC and lot release assays. In addition, production from a clonal Master Cell Bank minimizes lot-to-lot variability.
When preclinical development teams use the same reagents, handoffs can be that much easier as programs advance to later stages.
CAR+ Cell Enrichment in Manufacturing: Available Now: GMP-Grade G4S Linker (E7O2V) Rabbit Monoclonal Antibody (Biotin Conjugate) #22985
- Enrich CAR+ cells containing multiple G4S repeats with one reagent
- Biotin-conjugated antibodies are amenable to magnetic bead-based CAR-T cell enrichment on cell therapy manufacturing instrumentation
- Standardize percent CAR-positive cells and mitigate issues associated with low transduction efficiencies
- Reagents are designed and manufactured to GMP-grade reagent standards*
- Clonal Master Cell Bank ensures lot-to-lot consistency
CAR+ Cell Detection for Analytical QC: Available Now: GMP-Grade G4S Linker (E7O2V) Rabbit Monoclonal Antibody (PE Conjugate) #22996
- Detect CAR+ cells containing multiple G4S repeats with one reagent
- Simplify in-process QC and lot release assays
- PE-conjugated antibodies plug into your existing analytical flow cytometry panels
- Amenable to CAR+ cell detection in flow cytometry and FACS-based enrichment
- Reagents are designed and manufactured to GMP-grade reagent standards*
- Clonal Master Cell Bank ensures lot-to-lot consistency
Translational-Grade Recombinant Monoclonal Antibody Conjugates for Cell Therapy Manufacturing & QC Process Development
- Ideal for process development; a clear upgrade path to GMP-grade when needed
- Made in the same GMP-certified laboratory as GMP-grade conjugates, using the same processes
- Identical formulation and concentration with equivalent performance to GMP-grade conjugates
- Volume options make ordering the right size easy
- Extended documentation to support audit requirements
- Available globally, with fast shipping
- The translational-grade reagents are for Research Use Only (RUO) and not for use in manufacturing or quality control of commercial drug products or diagnostic procedures.
CAR+ Cell Enrichment Process Development: G4S Linker (E7O2V) Rabbit Monoclonal Antibody (Biotin Conjugate) (Translational-Grade) #80462
CAR+ Cell Detection for Analytical QC Process Development: G4S Linker (E7O2V) Rabbit Monoclonal Antibody (PE Conjugate) (Translational-Grade) #99539
